|
KMID : 0379520230390010135
|
|
한국독성학회지
2023 Volume.39 No. 1 p.135 ~ p.146
|
|
|
Anti-inflammatory effects of Athyrium yokoscense extract via inhibition of the Erk1/2 and NF-κB pathways in bisphenol A-stimulated A549 cells
|
|
Lee Jung-Kyu
Choi Won-Seok
Song Jin-Yong
Kwon Oh-Seong
Lee Yeon-jin
Lee Jong-Seok
Lee Sa-Rah
Choi Se-Rin
Lee Choong-Hwan
Lee Ji-Yun
|
|
|
Abstract
|
|
|
|
Bisphenol A is an environmental endocrine disruptor that has similar functions to estrogen in humans. However, few studies have investigated pulmonary inflammation induced by BPA, and the effect of Athyrium yokoscense extract on this inflammatory response is unknown. In this study, we investigated this effect in A549 human alveolar epithelial cells. BPA at concentrations higher than 100 μM were cytotoxic to A549 cells at 24 and 48 h after treatment; however, AYE (100 μg/mL) had a protective effect against BPA-induced cytotoxicity. AYE also inhibited the generation of intracellular reactive oxygen species, expressions of cyclooxygenase-2 and extracellular signal-regulated kinase1/2 proteins, activities of phospholipase A2, COX-2, nuclear factor kappa-light-chain-enhancer of activated B cells, and proinflammatory mediators including prostaglandin E2, tumor necrosis factor-α, and interleukin-6 induced by BPA in A549 cells. This study demonstrated that BPA, which induces chronic lung disease, causes oxidative stress and inflammatory response in lung epithelial cell line, and found that AYE reduces BPA-induced oxidative stress and inflammatory response by down-regulating the Erk1/2 and NF-κB pathways.
|
|
|
KEYWORD
|
|
|
Bisphenol A, Athyrium yokoscense, Inflammation, NF-κB, Erk1/2
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|
|